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Biophysics Group Group Logo representing molecular structure of RNA complex
The Biophysics Group (844.08) develops advanced spectroscopies, microscopies, nano-optical probes, and imaging technologies and associated theoretical models to solve important biophysics and bionanotechnology measurement science problems in the areas of biomolecular and cellular structure, function, interactions, and dynamics in support of the measurement and standards needs of the health care, biotechnology, and drug industries.

Our Vision: To enable the promise of systems biology, illuminating the small and rapidly changing components in a large and complex environment to elucidate fundamental underlying mechanisms of biological systems.

Research focus:
Measurement science in support of:

Structural Biophysics
• Novel spectroscopies and microscopies to elucidate biomolecular structure
• Theory and modeling to help interpret and guide such measurements

Functional and Dynamical Biophysics
• Imaging to delineate biomolecular mechanisms
• Spectroscopy for biomolecular dynamics
• Theory and modeling to elucidate underlying biophysics

Systems Biology
• Complementary measurements to address complex problems
• Integrated measurements for diagnostics and screening
• Nanobiological probes for more sensitive and selective detection
• First principles modeling to predict outcomes

Staff
  -  Gerald Fraser, Acting Group Leader
  -  Barbara Turner, Secretary

  -  Kimberly Briggman, Chemist
  -  Anne Chaka, Chemist
  -  Edwin Heilweil, Chemist
  -  Angela Hight Walker, Physicist
  -  Jeeseong Hwang, Biophysicist
  -  David Plusquellic, Chemist
  -  John Woodward, Physicist

  -  Postdocs, Students, and Guest Researchers


Resources 

Events
  -  Group Events
  -  NIST Events
  -  Conferences and Meetings


Research News
  -  Group News
  -  NIST News
  -  Hot news in Biophysics
  -  Division Annual Report


Research Highlights


Publications


Employment Opportunities
  -  NRC Postdocs
  -  Guest Researchers
  -  PhD Students
  -  Undergraduate Students
  -  Internship Program


Links
  -  JBI
  -  UMBI
  -  NCL/NCI/NIH

  

Research 

Continuous Wave Spectroscopy
  -   CW Terahertz (THz) Spectroscopy of Biomolecules
  -   CW Ultraviolet (UV) Spectroscopy of Biomolecules
  -   Jb95 Spectral Fitting Program


Nonlinear Optical Spectroscopy
  -   Vibrational Spectroscopy of Biological Interfaces
  -   Characterization of Supported Membranes
  -   Nonlinear Spectroscopy of Nanoparticles and Liposomes


Quantitative Molecular Imaging
  -   Optical Characterization of Novel Nanoprobes
  -   Bioinspired Self-assembly of Nanobiocomplexes
  -   Integrated Optical Measurement Platforms for Quantitative Dynamical Imaging
  -   Modeling and Characterizing Optical Properties of Nanocomplexes


Raman Spectroscopy
  -   Magnetic Nanoparticles
  -   Raman Spectroscopy of Carbon Nanotubes
  -   Quantitative Surface Enhanced Raman Spectroscopy


Single Molecule Microscopy and Spectroscopy
  -   Single Molecule Biophysics
  -   Hydrosomes
  -   Near-Field Optical Microscopy


Terahertz Metrology
  -   Ultrafast and CW THz Spectroscopy and Imaging
  -   Ultrafast THz Spectroscopy and Imaging of Biomolecules
  -   Femtosecond Transient Infrared Spectroscopy


Theoretical Computation and Modeling
  -   Theory and Modeling for Drug Design and Molecular Recognition
  -   Structure and Reactivity of Surfaces
  -   Predicting Properties of Nanostructures

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Online: February 2008